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(2016) Exposing the exposures responsible for type 2 diabetes and obesity. CrossRef 64 David Houghton, Christopher Stewart, Christopher Day, Michael Trenell. Wing, Terry Davidson, Leonard Epstein, Bret Goodpaster, Kevin D. Data were pooled from the diets for the two factorial comparisons: low fat versus high fat and average protein versus high protein. CrossRef 27 W Ma, T Huang, M Wang, Y Zheng, T Wang, Y Heianza, D Sun, S R Smith, G A Bray, F M Sacks, L Qi. Ito, Harold E. (2015) Health Benefits of Long-Term Weight-Loss Maintenance. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. NALLIAH, PRASHANTHAN SANDERS, JONATHAN M. Siri-Tarino, Sally Chiu, Nathalie Bergeron, Ronald M. Gallagher, H. The participants were eager to lose weight and to attempt whatever type of diet they were assigned, and they did well in screening interviews and questionnaires that evaluated their motivation. CrossRef 33 P. F. Dinani, Richard I. CrossRef 26 Yoriko Heianza, Wenjie Ma, Tao Huang, Tiange Wang, Yan Zheng, Steven R. Williams, K. (2014) Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results. Sacks is also vice-chair of the Nutrition Committee of the American Heart Association, which advises the Association on nutrition topics, including those related to overweight and obesity. (2016) Complex Relationships Between Food, Diet, and the Microbiome. 2014. 67-kg weight loss as an effect of the level of protein or fat in the diet over the 2-year period, assuming a withdrawal rate of 40%. Adobe Flash Player is required to view this feature. ) 36 Mensink RP, Zock PL, Kester AD, Katan MB. Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial. CrossRef 170 Peter C. Turner, William S. The Molecular Nutrition of Amino Acids and Proteins, 221-232. I. A. Nickols-Richardson. Ebbeling. (2016) The effects on weight loss and gene expression in adipose and hepatic tissues of very-low carbohydrate and low-fat isoenergetic diets in diet-induced obese mice. Nalliah, Prashanthan Sanders. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2015) Fruit and Vegetable Consumption and Changes in Anthropometric Variables in Adult Populations: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. Only two trials have reported dietary intake beyond 1 year, 12,26 and one of them provided foods to the participants. CrossRef 60 Roger A. Carson, J. L. Ikizler, L. P. 4 percentage points, respectively, at 6 months and 6. CrossRef 146 Michelle Crino, Gary Sacks, Stefanie Vandevijvere, Boyd Swinburn, Bruce Neal. Roos, Nigel K. E. Adobe Flash Player is required to view this feature. The primary outcome was the change in body weight after 2 years in two-by-two factorial comparisons of low fat versus high fat and average protein versus high protein and in the comparison of highest and lowest carbohydrate content. CrossRef 17 Tomomi Yamazaki, Sumire Okawa, Mayumi Takahashi. Kurland, Stefan Judex. CrossRef 98 (2015) Obesity and reproduction: a committee opinion. Major criteria for exclusion were the presence of diabetes or unstable cardiovascular disease, the use of medications that affect body weight, and insufficient motivation as assessed by interview and questionnaire. M. Adobe Flash Player is required to view this feature. CrossRef 16 Michelle Crino, Gary Sacks, Jason H. After 12 months, all groups, on average, slowly regained body weight. Satiety, hunger, satisfaction with the diet, and attendance at group sessions were similar for all diets. CrossRef 172 B. (2015) Personality, attrition and weight loss in treatment seeking women with obesity. An immunotherapy drug to bolster a T cell surge. Adobe Flash Player is required to view this feature. CrossRef 99 Jonathan Sackner-Bernstein, David Kanter, Sanjay Kaul, Allan Siegel. (2014) Lifestyle Interventions for Cardiovascular Disease Risk Reduction: A Systematic Review of the Effects of Diet Composition, Food Provision, and Treatment Modality on Weight Loss. 3 cm per month of regained waist circumference after withdrawal (see Methods in the Supplementary Appendix ). CrossRef 12 Junghwan Kim. Reynolds, T. Reavis. Stone. CrossRef 29 Sunita M. Effect of normal-fat diets, either medium or high in protein, on body weight in overweight subjects: a randomised 1-year trial. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Bays, W. McCarthy. Long-term effects of 2 energy-restricted diets differing in glycemic load on dietary adherence, body composition, and metabolism in CALERIE: a 1-y randomized controlled trial. (2014) Diet and lifestyle interventions on lipids: combination with genomics and metabolomics. Adobe Flash Player is required to view this feature. Roberts. Thus, we recognized the need for a large trial that would be designed to overcome the limitations of previous trials and that would compare the effects of three principal dietary macronutrients. Journal of Cardiopulmonary Rehabilitation and Prevention 35, 81-92. Anti-cancer drug ONC201 shows potential for some blood cancers. K. Russell Lectureship and Joanne Vandenberge Hill Award in. Evans, R. Farrell. 1,2,26 Investigators and staff who measured outcomes were unaware of the diet assignment of the participants. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. The principal finding is that the diets were equally successful in promoting clinically meaningful weight loss and the maintenance of weight loss over the course of 2 years. A total of 403 participants were assigned to a high-protein diet and 408 to an average-protein diet, 405 were assigned to a high-fat diet and 406 to a low-fat diet, and 204 were assigned to the highest-carbohydrate diet and 201 to the lowest-carbohydrate diet. Halldorsson, A. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Coffman, Stephanie Mayer, William S. Sharma. Keller. Obesity Management for the Treatment of Type 2 Diabetes. CrossRef 38 Satya Sharma, Hea Chung, Hyeon Kim, Seong Hong. King, A. (2015) Comparative effectiveness of plant-based diets for weight loss: A randomized controlled trial of five different diets. Crowe. It is therefore not surprising that attendance at group sessions was strongly related to adherence to high-protein or low-fat goals but not to the goals in the average-protein or high-fat groups. Devassy, Stephanie P. K. Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: a randomized controlled trial. (2014) Unravelling of the health effects of polyphenols is a complex puzzle complicated by metabolism. L. Effects of Different Dietary Fibers on Sugar-Induced Blood Pressure Elevations in Hypertensive Rats: Focus on Viscosity. Ard, Gary Miller, Scott Kahan. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Dietary and Lifestyle Strategies for Weight Loss. Hanna. Malhotra, K. The mean differences among the groups in fat, carbohydrate, or protein intake at 6 months were nevertheless often greater than those in several previous trials comparing diets for weight loss. Williams, Rachel C. Yancy. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. The goal for physical activity was 90 minutes of moderate exercise per week. Krumhar. 2016. Open bars represent average-protein, low-fat, or lowest-carbohydrate diets. Bloom. Adobe Flash Player is required to view this feature. (2016) Endoscopic Devices for Obesity. The study was powered to detect a 1. Effect of an energy-restricted, high-protein, low-fat diet relative to a conventional low-fat, high-carbohydrate diet on weight loss, body composition, nutritional status, and markers of cardiovascular health in obese women. Johnson, Linda C. We used a generic approach to developing each diet and the instructions for following it, in order to minimize such influences. Bertin, B. Yancy. Endoluminal Procedures for the Treatment and Management of Bariatric Patients. S. Jones, Penny Kris-Etherton, Geeta Sikand, Ralph La Forge, Stephen R. (2016) A randomized pilot study of dietary treatments for polycystic ovary syndrome in adolescents. Immune suppressor cells linked to prostate tumor growth. ) Full Text of Discussion. Aronne. Blood pressure was measured with the use of an automated device (HEM-907XL, Omron). Mariotti. The participants who completed the study had a mean weight loss of 6. Obesity Management for the Treatment of Type 2 Diabetes. Zurbau, H. (2016) The therapeutic potential of metabolic hormones in the treatment of age-related cognitive decline and Alzheimer disease. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. The participants were offered group and individual instructional sessions for 2 years. Effects of total fat intake on body weight. (2016) Randomized clinical trial of portion-controlled prepackaged foods to promote weight loss. V. CrossRef 13 Nicola Guess. 12,24,37,38 These findings together point to behavioral factors rather than macronutrient metabolism as the main influences on weight loss. 2, and 14. Regain after 6 to 12 months was about 20% of the regain reported in earlier trials. (2016) Predictors of weight regain in patients who underwent Roux-en-Y gastric bypass surgery. Adobe Flash Player is required to view this feature. (2015) Treatment of Obesity in 2015. Journal of the Academy of Nutrition and Dietetics 116:6, 968-983. CrossRef 149 B. (2015) Technology-Assisted Weight Loss Interventions in Primary Care: A Systematic Review. (2015) Sorghum: An Underutilized Cereal Whole Grain with the Potential to Assist in the Prevention of Chronic Disease. Abstract Background The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Panel D shows the change in waist circumference for the 599 participants who provided measurements at 2 years. Sanders. Adobe Flash Player is required to view this feature. Comparison of a low carbohydrate and low fat diet for weight maintenance in overweight or obese adults enrolled in a clinical weight management program. (2015) Mindful Eating. Panel B shows the change in body weight for participants who provided measurements at various time points: 176 to 180 participants at 6 months, 157 to 167 at 12 months, 140 to 152 at 18 months, and 151 to 168 at 2 years. CrossRef 121 Lee Hooper, Nicole Martin, Asmaa Abdelhamid, George Davey Smith, Lee Hooper. (2016) NIH working group report-using genomic information to guide weight management: From universal to precision treatment. 2016. (2016) Adherence to low-carbohydrate and low-fat diets in relation to weight loss and cardiovascular risk factors. Study links high sugar intake to increased breast cancer risk. 12 In addition, trials of low-carbohydrate diets have reported a very low incidence of urinary ketosis after 6 months, 6,8,12 suggesting that in most overweight people, it is futile to sustain a low intake of carbohydrates. The crucial question is whether overweight people have a better response in the long term to diets that emphasize a specific macronutrient composition. Protein and fat intakes overlapped among the groups. A low-fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Wong, M. CrossRef 97 Shelby Sullivan, Nitin Kumar, Steven A. Overall, these findings with respect to adherence to macronutrient goals suggest that participants in weight-loss programs revert to their customary macronutrient intakes over time but may nonetheless be able to maintain weight loss. (2016) Higher protein intake is associated with increased risk for incident end-stage renal disease among blacks with diabetes in the Southern Community Cohort Study. Daumit. Au-Yeung, A. Tucker. Adobe Flash Player is required to view this feature. Rothman, Donna Ryan. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2015) Biologic Responses to Weight Loss and Weight Regain: Report From an American Diabetes Association Research Symposium. Kramer. (2015) Determining how best to support overweight adults to adhere to lifestyle change: protocol for the SWIFT study. Kuchenbecker, Annemieke Hoek. (2016) Through Thick and Thin: Identifying Barriers to Bariatric Surgery, Weight Loss Maintenance, and Tailoring Obesity Treatment for the Future. CrossRef 102 Lukas Schwingshackl, Georg Hoffmann, Tamara Kalle-Uhlmann, Maria Arregui, Brian Buijsse, Heiner Boeing, Elizabeth W Triche. CrossRef 182 N Germain, B Galusca, D Caron-Dorval, J-F Martin, E Pujos-Guillot, Y Boirie, Y Khalfallah, Y Ling, J S Minnion, S R Bloom, J Epelbaum, B Estour. In contrast, the participants in the high-protein or low-fat groups had more challenging dietary goals. J. C. Craving, fullness, and hunger and diet-satisfaction scores were similar at 6 months and at 2 years among the diets (Table 2 in the Supplementary Appendix ). CrossRef 126 O. Affordable Care Act is boosting prevention, but more work is needed. Panel D shows the change in waist circumference for participants who provided measurements at various time-points: 176 to 179 at 6 months, 154 to 166 at 12 months, 135 to 148 at 18 months, and 137 to 159 at 2 years. Sights set on first targeted therapy for triple-negative breast cancer. Dietary intake in the lower Mississippi delta region: results from the Foods of Our Delta Study. The American Journal of Medicine 127, 1242. (2015) The diet-heart hypothesis, obesity and diabetes. (2016) Functionality of Sugars in Foods and Health. (2016) Obstructive Sleep Apnea Treatment and Atrial Fibrillation: A Need for Definitive Evidence. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Astrup, S. (2015) Dietary restriction in moderately obese rats improves body size and glucose handling without the renal and hepatic alterations observed with a high-protein diet. The study was approved by the human subjects committee at each institution and by a data and safety monitoring board appointed by the National Heart, Lung, and Blood Institute. (2014) Low carbohydrate diets: going against the grain. Adobe Flash Player is required to view this feature. Azrin, Denise Juliano-Bult, Gail L. Virgil Brown. 2 percentage points, respectively, at 2 years. Nutrition in Weight Management and Obesity. Cohen, Samuel Dagogo-Jack, Jaime Davidson, Daniel Einhorn, Om Ganda, Alan Garber, W. Blot, T. Risk factors for cardiovascular disease and diabetes were also analyzed according to the intention-to-treat principle, with zero change from baseline imputed for missing data. CrossRef 59 Deborah L. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Lipworth, E. Changes from baseline differed among the diet groups by less than 0. European Heart Journal - Cardiovascular Pharmacotherapy 1, 74-75. (2015) Management of obesity: improvement of health-care training and systems for prevention and care. Reviews in Endocrine and Metabolic Disorders 15, 317-327. 5 kg at 6 months, which corresponds to a reduction in daily energy intake of approximately 225 kcal. CrossRef 90 Tao Huang, Frank B Hu. Results of the what to eat for lunch study. gov number, NCT00072995. Stanton. Effect of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Saris, Arne Astrup. Adobe Flash Player is required to view this feature. I bars in all panels indicate standard errors. Hills, N. Maslova, T. Teams work to enhance care, reduce costs and define quality. 1 in the Supplementary Appendix ). Adobe Flash Player is required to view this feature. CrossRef 158 Janet Walberg Rankin. M. (2015) Dietary protein-to-carbohydrate ratio and added sugar as determinants of excessive gestational weight gain: a prospective cohort study. B. 0, 4. Searching for those at high risk for pancreatic cancer. Daily meal plans in 2-week blocks were provided (see the Supplementary Appendix ). (2016) Metabolic syndrome, diet and exercise. CrossRef 6 Tracey Ledoux, Tabbetha Lopez, Craig Johnston, Elizabeth Vaughan, John P. Hu, L. P values for a trend in weight loss across quintiles are as follows: P ). Gooding, H. A. Bray, MD: Progress in Obesity—Multidisciplinary Research, Multidimensional Man. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Duvnjak, J. Ogunleye, Arya M. Feldman, C. MD Anderson experts named to National Cancer Moonshot advisory panel. (2016) Food preferences and weight change during low-fat and low-carbohydrate diets. e19. Arden. Meta-analysis: the effect of dietary counseling for weight loss. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. Adobe Flash Player is required to view this feature. 2015. Franks, M. Y. Telem, Darragh Herlihy, Kathryn Cottell, Aurora D. (2016) A Review of Population-Level Actions Targeting Reductions in Food Portion Sizes to Address Obesity and Related Non-communicable Diseases. CrossRef 157 Je Rossouw. (2015) Effects of nutrition education on weight gain prevention: a randomized controlled trial. CrossRef 167 Anne-Thea McGill. CrossRef 53 Yasuyuki Nakamura, Hirotsugu Ueshima, Nagako Okuda, Katsuyuki Miura, Yoshikuni Kita, Naoko Miyagawa, Katsushi Yoshita, Hideaki Nakagawa, Kiyomi Sakata, Shigeyuki Saitoh, Tomonori Okamura, Akira Okayama, Sohel R. (2016) The Effects of Increased Protein Intake on Fullness: A Meta-Analysis and Its Limitations. Adobe Flash Player is required to view this feature. Deane, Amarjit Saini, Colin Selman, Claire E. Adobe Flash Player is required to view this feature. (2016) Two-year changes in circulating adiponectin, ectopic fat distribution and body composition in response to weight-loss diets: the POUNDS Lost Trial. Popular diets and over-the-counter dietary aids and their effectiveness in managing obesity. (2015) Effect of a 4-week weight maintenance diet on circulating hormone levels: implications for clinical weight loss trials. Ard. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Endocrinology and Metabolism Clinics of North America 45:3, 565-580. The project staff of the National Heart, Lung, and Blood Institute also participated in the development of the protocol, monitoring of progress, interpretation of results, and critical review of the manuscript. Of these participants, 303 were assigned to a high-protein diet and 296 to an average-protein diet, 292 were assigned to a high-fat diet and 307 to a low-fat diet, and 159 were assigned to the highest-carbohydrate diet and 155 to the lowest-carbohydrate diet. R. Of these participants, 325 were assigned to a high-protein diet and 320 to an average-protein diet, 319 were assigned to a high-fat diet and 326 to a low-fat diet, and 169 were assigned to the highest-carbohydrate diet and 168 to the lowest-carbohydrate diet. Brook Singletary, Adeena Menasha, Clarissa Cooblall, Donald Hantula, Saul Axelrod, Vincent M. M. Steffen, L. A high-protein intake was associated with weight loss only in the high-protein groups, and a low-fat intake was associated with weight loss only in the low-fat groups. Conformity to cultural norms, scientific novelty, and media attention are nonbiologic reasons for the success of specific diets. Rolls, R. 2016. Diabetes and Non-Alcoholic Fatty Liver Disease. Reduction in saturated fat intake for cardiovascular disease. CrossRef 165 Megan A. Thus, two diets were low-fat and two were high-fat, and two were average-protein and two were high-protein, constituting a two-by-two factorial design. CrossRef 101 Harry Preuss, Debasis Bagchi, Dallas Clouatre, Anand Swaroop, Nicholas Perricone. Rana, Loki Natarajan. CrossRef 178 (2014) Chapter 1 Assessment and Risk Management of Menopausal Women. e18. Olsen. G. The analysis also included a comparison of two of the four diets, the diet with the lowest carbohydrate content and the diet with the highest carbohydrate content, and included a test for trend across the four levels of carbohydrates. Randomized trial of protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Journal of Clinical Lipidology 9:6, S1-S122. (ClinicalTrials. Panel B shows the change in body weight for the 645 participants who provided measurements at 2 years. Ziegler, E. Effects of moderate variations in macronutrient composition on weight loss and reduction in cardiovascular disease risk in obese, insulin-resistant adults. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Wingo, T. Endocrinology and Metabolism Clinics of North America 45:3, 581-604. (2016) Using a wider lens to shift the discourse on food in Canadian curriculum policies. Adobe Flash Player is required to view this feature. (2016) The Role of Macronutrient Content in the Diet for Weight Management. CrossRef 112 Lu Qi. W. CrossRef 9 A. We caution that these post hoc analyses do not have the strong validity of the main analysis of this controlled trial, which compared randomized groups. Adobe Flash Player is required to view this feature. B. Seeley, Tamara Darsow, Erika Gebel Berg, Steven R. A randomized trial of a low-carbohydrate diet for obesity. V. Carbohydrate-rich foods with a low glycemic index were recommended in each diet. Sidney Barritt, Yvon Calmus, Olivier Scatton, Thomas Runge, Pascal Lebray, Thierry Poynard, Vlad Ratziu, Filomena Conti. Adobe Flash Player is required to view this feature. CrossRef 138 Tao Huang, Jinyan Huang, Qibin Qi, Yanping Li, George A. Adobe Flash Player is required to view this feature. CrossRef 166 Emilie Daoud, Celena Scheede-Bergdahl, Andreas Bergdahl. (2015) Concentrating carbohydrates before sleep improves feeding regulation and metabolic and inflammatory parameters in mice. Calvar, F. Alfredo Martinez, Santiago Navas-Carretero, Wim H. 11,12,19,21,26 Substantially diminished adherence after the first few months is typical in weight-loss trials 5,6,8,10-12,19,21,24,26 and occurred between 6 months and 2 years in our trial. 2015. CrossRef 32 John Grizzanti, Hyoung-Gon Lee, Antoni Camins, Merce Pallas, Gemma Casadesus. First-of-its-kind study examines cosmetic outcomes for older breast. CrossRef 127 Ingrid Elizabeth Lofgren. Thus, changes in biomarkers confirmed that differences among the groups in macronutrient intake were consistent with those recorded in the dietary reports and that participants modified their intake of macronutrients in the direction of the goals, although the targets were not fully achieved. Solid bars represent high-protein, high-fat, or highest-carbohydrate diets. Menendez, Jorge Joven. Adobe Flash Player is required to view this feature. Adobe Flash Player is required to view this feature. (2014) The Epidemiology of Obesity: A Big Picture. Fasting blood samples, 24-hour urine samples, and measurement of resting metabolic rate were obtained on 1 day, and blood-pressure measurement on 2 days, at baseline, 6 months, and 2 years. Sacks is a member of the Lifestyle Working Group of the Expert Panel that interacts with the Obesity Committee. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. L. CrossRef 160 Adela Hruby, Frank B. (2014) Specific appetite, energetic and metabolomics responses to fat overfeeding in resistant-to-bodyweight-gain constitutional thinness. CrossRef 159 Jennifer Arussi. Drug shows promise for patients with certain gene fusions. Jonnalagadda, Michael Larsen, Christopher C. (2016) Physical Activity and Dietary Determinants of Weight Loss Success in the US General Population. Heath, Kim C. Obesity and Diabetes. Adobe Flash Player is required to view this feature. CrossRef 72 Patrick Wilson. (2016) Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status. (2016) Paradoxical Effects of Fruit on Obesity. Open bars represent average-protein, low-fat, or lowest-carbohydrate diets. Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods, 41-52. The study had a large sample, a high rate of retention, and the sensitivity to detect small changes in weight. Carbohydrate restricted diets high in either monounsaturated fat or protein are equally effective in promoting fat loss and improving blood lipids. Whelton, J. Adobe Flash Player is required to view this feature.
(2015) Reducing weight in an internal medicine outpatient clinic using a lifestyle medicine approach: A proof of concept. CrossRef 31 Prapimporn Chattranukulchai Shantavasinkul, Philip Omotosho, Leonor Corsino, Dana Portenier, Alfonso Torquati. CrossRef 142 H P F Peters, W P Koppenol, E A H Schuring, S L Abrahamse, D J Mela. Watson. (2015) Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Thus, a low-fat intake of 25% was associated with increased weight loss in the low-fat groups but not in the high-fat groups, and a high-protein intake of 24 to 25% was associated with increased weight loss in the high-protein groups but not in the average-protein groups. Jouret, R. The diets improved lipid risk factors and fasting insulin levels in the directions that would be expected on the basis of macronutrient content. Discovery may lead to earlier treatment of inflammation-linked cancers. CrossRef 120 Ulf Elbelt, Tatjana Schuetz, Nina Knoll, Silke Burkert. (2015) An energy-reduced dietary pattern, including moderate protein and increased nonfat dairy intake combined with walking promotes beneficial body composition and metabolic changes in women with excess adiposity: a randomized comparative trial. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. M. (2016) Metabolic Syndrome: An Evolving Clinical Construct. Lifestyle Issues: Diet. (2014) Metabolic syndrome and lifestyle modification. Mordes, Chao Liu, Shuhang Xu. 5 kg of body weight and 0. Spiro, S. CrossRef 141 Caroline K. CrossRef 113 Lee Hooper, Asmaa Abdelhamid, Diane Bunn, Tracey Brown, Carolyn D Summerbell, C Murray Skeaff, Lee Hooper. Surgery for Obesity and Related Diseases 11, 431-435. New partnerships push innovative approaches to cancer treatment forward. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Slavin, Svetlana Zivanovic. Study sheds light on deadly form of breast cancer. Stewart. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. The ranges of protein and fat intakes overlapped substantially in the diet groups. (2015) Saturated Fats Versus Polyunsaturated Fats Versus Carbohydrates for Cardiovascular Disease Prevention and Treatment. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Primary Care: Clinics in Office Practice 43:1, 145-158. CrossRef 128 Harry Preuss, Dallas Clouatre. South African Journal of Clinical Nutrition 28:1, 38-43. Rothstein. World Cancer Day reflects the daily mission of MD Anderson. Citing Articles 1 Danny Weathers, Jennifer Christie Siemens, Steven W. CrossRef 163 O. H. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. (2015) Long-term adherence to the New Nordic Diet and the effects on body weight, anthropometry and blood pressure: a 12-month follow-up study. Stem Cell Transplantation and Cellular Therapy Center Home. These changes in risk factors in the intention-to-treat population were about 30 to 40% smaller than the changes seen among participants who provided data at 2 years, reflecting the effect of the imputation of missing values (Table 1 in the Supplementary Appendix ). Kopp. (2016) Surgical Weight Loss and Atrial Fibrillation. Conclusions Reduced-calorie diets result in clinically meaningful weight loss regardless of which macronutrients they emphasize. Adherence, Diet Acceptability, Satiety, and Satisfaction Mean reported intakes at 6 months and 2 years did not reach the target levels for macronutrients ( Table 2 ). If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Depression shortens head and neck cancer survival time, increases recurrence. (2016) Salba-chia (Salvia hispanica L. W. Journal of Obstetrics and Gynaecology Canada 38:6, 555-610. Strategies for the Prevention of Type 2 Diabetes. Journal of Obstetrics and Gynaecology Canada 36:9, S6-S15. (2016) Impact of food supplementation on weight loss in randomised-controlled dietary intervention trials: a systematic review and meta-analysis. Seimon, N. Ludwig, C. 3 kg per month of regained weight 34 and a rate of 0. (2015) ASGE position statement on endoscopic bariatric therapies in clinical practice. We explored the association of achieved nutrient intakes with weight loss. CrossRef 50 T Wang, T Huang, Y Zheng, J Rood, G A Bray, F M Sacks, L Qi. Thus, the participants assigned to an average-protein or high-fat diet did not have to change their customary level of dietary protein and fat very much and could focus more on reducing dietary intake. (2015) Self-Directed Weight Loss Strategies: Energy Expenditure Due to Physical Activity Is Not Increased to Achieve Intended Weight Loss. CrossRef 168 Harry Preuss, Jeffrey Preuss. CrossRef 95 Daniela Lucini, Giovanna Cesana, Chiara Vigo, Mara Malacarne, Massimo Pagani. Discussion In this population-based trial, participants were assigned to and taught about diets that emphasized different contents of carbohydrates, fat, and protein and were given reinforcement for 2 years through group and individual sessions. Adobe Flash Player is required to view this feature. Aukema. CrossRef 52 J. Implantable devices track cardiac events in cancer patients. CrossRef 162 Mitsuyoshi Takahara, Iichiro Shimomura. 2015. CrossRef 133 Yehuda Handelsman, Zachary Bloomgarden, George Grunberger, Guillermo Umpierrez, Robert Zimmerman, Timothy Bailey, Lawrence Blonde, George Bray, A. Siri-Tarino. CrossRef 86 Qibin Qi, Yan Zheng, Tao Huang, Jennifer Rood, George A. Surgery for Obesity and Related Diseases 12:9, 1640-1645. Jouret, R. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Frongillo. 2017. Comparison of strategies for sustaining weight loss: the Weight Loss Maintenance randomized controlled trial. Krystal. Journal of the American College of Cardiology 68:23, 2505-2507. CrossRef 65 Cinthya Wibisono, Yasmine Probst, Elizabeth Neale, Linda Tapsell. Adobe Flash Player is required to view this feature. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2016) Dietary protein from different food sources, incident metabolic syndrome and changes in its components: An 11-year longitudinal study in healthy community-dwelling adults. Media in This Article Poll Results Contributors Figure 1 Mean Change in Body Weight and Waist Circumference from Baseline to 2 Years According to Dietary Macronutrient Content. e10. (2015) Weight Loss Is a Useful Therapeutic Objective. 2017. Panel B shows the change in body weight for the 645 participants who provided measurements at 2 years. 4, and 10. Caligiuri, Shyamchand Mayengbam, Naser H. Adobe Flash Player is required to view this feature. The ratio of urinary microalbumin to creatinine was more than 30 in five participants in the average-protein group and in five participants in the high-protein group at 6 months and in seven participants, all in the average-protein groups, at 2 years. Hu. MD Anderson experts join new Parker Institute for Cancer Immunotherapy. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2016) Genetic variation of fasting glucose and changes in glycemia in response to 2-year weight-loss diet intervention: the POUNDS LOST trial. Some breast cancer patients may avoid surgery in future. Sievenpiper, R. (2015) Primary endoscopic therapies for obesity and metabolic diseases. Statistical Analysis The primary outcome of the study was the change in body weight over a period of 2 years, and the secondary outcome was the change in waist circumference. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2015) Gene-environment interactions and obesity: recent developments and future directions. (NIH publication no. C. (2016) Meta-analysis of variance: an illustration comparing the effects of two dietary interventions on variability in weight. Panel D shows the change in waist circumference for the 599 participants who provided measurements at 2 years. A low-carbohydrate as compared with a low-fat diet in severe obesity. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Of these participants, 303 were assigned to a high-protein diet and 296 to an average-protein diet, 292 were assigned to a high-fat diet and 307 to a low-fat diet, and 159 were assigned to the highest-carbohydrate diet and 155 to the lowest-carbohydrate diet. (2015) NIH working group report: Innovative research to improve maintenance of weight loss. CrossRef 175 Deirdre Tobias, Wei Bao. They were informed that the study would be comparing diets with different fat, protein, and carbohydrate contents and that they would be assigned a diet at random. 2015. CrossRef 109 Vivek Kumbhari, Andreas Oberbach, Ashish Nimgaonkar. (2015) Interventions to Address Medical Conditions and Health-Risk Behaviors Among Persons With Serious Mental Illness: A Comprehensive Review. CrossRef 56 Deepinder Goyal, Rabindra R. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2015) The effect of a low-energy food foam on appetite measures during a 1-day reduced-energy meal plan. 02-5215. I bars in all panels indicate standard errors. Panel B shows the change in body weight for participants who provided measurements at various time points: 176 to 180 participants at 6 months, 157 to 167 at 12 months, 140 to 152 at 18 months, and 151 to 168 at 2 years. Sabin gift encourages research that tests the limits, delivers big impact. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. CrossRef 140 Sanne Kellebjerg Poulsen, Charlotte Crone, Arne Astrup, Thomas Meinert Larsen. Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women. 2017. Levine, Stella Savarimuthu, Allison Squires, Joseph Nicholson, Melanie Jay. CrossRef 171 Jim Mann, Rachael McLean, Murray Skeaff, Lisa Te Morenga. 2015. Minniti, G. (2014) Effects of Dietary Macronutrients on Plasma Lipid Levels and the Consequence for Cardiovascular Disease. Participants Our goal was to recruit 800 overweight and obese subjects (400 at each site), of whom about 40% would be men. (2016) Gut Microbiota and Lifestyle Interventions in NAFLD. A. Despite the intensive behavioral counseling in our study, participants had difficulty achieving the goals for macronutrient intake of their assigned group. Driver, Neil J. Participation in exercise was monitored by questionnaire 30 and by the online self-monitoring tool. Adobe Flash Player is required to view this feature. Tan, Stephen R. Staff and participants were taught that each diet adhered to principles of a healthful diet 29 and that each had been recommended for long-term weight loss, thereby establishing equipoise. Laitner, Michael G. CrossRef 147 R. Hollman. CrossRef 15 Shivakumar Chitturi, Geoffrey C. House, Harold M. Figure 2 Mean Changes in Body Weight and Waist Circumference at Various Time Points. Rates of attendance at group sessions (percent of total sessions attended over the 2-year period) are shown for the quintiles of fat and protein intake. (2015) Strategies for the prevention of knee osteoarthritis. Scott Lapinski, Mariana Lazo, John H. The diets improved lipid-related risk factors and fasting insulin levels. Wadden. Ebeling, Kerrie M. Levels of serum lipids, glucose, insulin, and glycated hemoglobin were measured at the clinical laboratory at the Pennington Biomedical Research Center. The role of dietary energy density in weight management. (2015) National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2. Study participants who attended two thirds of the sessions over the course of 2 years lost about 9 kg of weight. (2015) The Influence on Population Weight Gain and Obesity of the Macronutrient Composition and Energy Density of the Food Supply. The Molecular Nutrition of Amino Acids and Proteins, 13-25. Ziegler, E. (2016) Nutrition Interventions for Obesity. Perri. Amankwaah, Katherene Osei-Boadi Anguah, Ashley Jacobs, Blake L. Ho, L. Harry Carothers Wiess Distinguished University Chair for Cancer Research. The reported intakes represented differences from target levels of fat, protein, and carbohydrate intake of 8. e. Thompson. Mattes, Robin M. (2016) Moderate Alcohol Consumption and Chronic Disease: The Case for a Long-Term Trial. Vassy, Tanya Agurs-Collins,. CrossRef 181 Yan Zheng, Lu Qi. (2014) Pre-ordering lunch at work. (2015) Obesity: Lifestyle management, bariatric surgery, drugs, and the therapeutic exploitation of gut hormones. 2016. CrossRef 77 Donevan Westerveld, Dennis Yang. Measurements Body weight and waist circumference were measured in the morning before breakfast on 2 days at baseline, 6 months, and 2 years, and on a single day at 12 and 18 months. Protein Intake Throughout Life and Current Dietary Recommendations. (2014) Diet during Pregnancy and Gestational Weight Gain. Bethesda, MD: National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institutes of Health, 2002. Dr. Gordon, D. Josse, A. Journal of Obstetrics and Gynaecology Canada 38:6, 508-554. (2014) Factors associated with choice of a low-fat or low-carbohydrate diet during a behavioral weight loss intervention. Marchesini. Adobe Flash Player is required to view this feature. CrossRef 36 Xianwen Shang, David Scott, Allison Hodge, Dallas R. CrossRef 91 Deirdre K Tobias, Mu Chen, JoAnn E Manson, David S Ludwig, Walter Willett, Frank B Hu. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A to Z Weight Loss Study: a randomized trial. Random assignments to one of four diet groups were generated by the data manager at the coordinating center on request of a study dietitian, after eligibility of a participant was confirmed. M. We performed an intention-to-treat analysis in which long-term weight loss for persons who withdrew from the study early (after at least 6 months of participation) was imputed on the basis of a rate of 0. Fuss, Edward Saltzman, Susan B. Other goals for all groups were that the diets should include 8% or less of saturated fat, at least 20 g of dietary fiber per day, and 150 mg or less of cholesterol per 1000 kcal. (2015) Effective Diet and Exercise Interventions to Improve Body Composition in Obese Individuals. Nickols-Richardson. Development of phenolic compounds encapsulation techniques as a major challenge for food industry and for health and nutrition fields. Buniak, Louis J. Obesity research -- limitations of methods, measurements, and medications. Adobe Flash Player is required to view this feature. (2016) The National Obesity Forum report is an opinion piece not a scientific review. A randomized controlled trial of a moderate-fat, low-energy diet compared with a low fat, low-energy diet for weight loss in overweight adults. 7, 1. M. Cavanaugh, W. (2017) Diets High in Fat or Fructose Differentially Modulate Bone Health and Lipid Metabolism. , provided a body-weight measurement at 2 years) (Fig. 2015. CrossRef 124 Chunlong Mu, Yuxiang Yang, Zhen Luo, Weiyun Zhu. Participants had to be 30 to 70 years of age and have a body-mass index (the weight in kilograms divided by the square of the height in meters) of 25 to 40. M. (2016) Effects of a Low-carbohydrate, High-fat Diet. We view attendance at counseling sessions as a proxy for commitment to achieving weight loss and for engagement in the program. Smith, Robert Ratner. Bertin, B. A two-year randomized weight loss trial comparing a vegan diet to a more moderate low-fat diet. Adobe Flash Player is required to view this feature. Johner, K. He, L. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. CrossRef 139 E. Gene-Diet Interaction and Weight Management. J. Longo, Michelle Harvie. A self-regulation program for maintenance of weight loss. Intake was determined from three 24-hour diet recalls. Adobe Flash Player is required to view this feature. Lifestyle Intervention for Resumption of Ovulation in Anovulatory Women with Obesity and Infertility. 2015. Adobe Flash Player is required to view this feature. Wingard, Sara Wilcox, Edward A. Colombari, A. Adobe Flash Player is required to view this feature. A low-carbohydrate ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. CrossRef 68 T. Adobe Flash Player is required to view this feature. Norman. Adobe Flash Player is required to view this feature. A total of 403 participants were assigned to a high-protein diet and 408 to an average-protein diet, 405 were assigned to a high-fat diet and 406 to a low-fat diet, and 204 were assigned to the highest-carbohydrate diet and 201 to the lowest-carbohydrate diet. CrossRef 84 F. (2014) Differences in weight loss and health outcomes among African Americans and whites in multicentre trials. Most of the weight loss occurred in the first 6 months. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2016) Epigenetics and nutrition-related epidemics of metabolic diseases: Current perspectives and challenges. Blinding was maintained by the use of similar foods for each diet. Tapsell. Yao, K. Benefits of lifestyle modification in the pharmacologic treatment of obesity: a randomized trial. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. 5 cm of waist circumference ( Figure 2 ). 2015. Delaying chemo for breast cancer reduces overall survival. Adobe Flash Player is required to view this feature. The diets consisted of similar foods and met guidelines for cardiovascular health. However, attendance had a strong association with weight loss, and the association was similar across diet groups. CrossRef 30 Xirong Zheng, Jing Deng, Ting Zhang, Jianzhuang Yao, Fang Zheng, Chang-Guo Zhan. A. Participants were instructed to record their food and beverage intake in a daily food diary and in a Web-based self-monitoring tool that provided information on how closely their daily food intake met the goals for macronutrients and energy. 2015. (2014) Personalized nutrition and obesity. Journal of Cardiovascular Development and Disease 1, 201-213. (2015) Metabolomic analysis reveals distinct profiles in the plasma and urine of rats fed a high-protein diet. Adobe Flash Player is required to view this feature. Team is the heart of the Head and Neck Center. (2016) Endoscopic Bariatric Therapies. (2016) Potential anti-obesity effects of a long-acting cocaine hydrolase. I. (2016) NAFLD and liver transplantation: Current burden and expected challenges. Simpson, David Raubenheimer. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Mastectomy plus reconstruction equals rise in complication rates, costs. Sainsbury, I. Stefanadis,. CrossRef 41 Naji Alamuddin, Thomas A. Top names in cancer unite in call for ban on tanning beds. De Sousa, Robert J. Adobe Flash Player is required to view this feature. Genotype Modifies Effect of a Weight-Loss Diet on 2-Year Changes of Insulin Resistance: The POUNDS LOST Trial. Kabagambe. Potential of Diet and Dietary Supplementation to Ameliorate the Chronic Clinical Perturbations of Metabolic Syndrome. A. Behavioral counseling was integrated into the group and individual sessions to promote adherence to the assigned diets. (2014) Personalized weight loss strategies—the role of macronutrient distribution. (2017) Tracking food intake as bites: Effects on cognitive resources, eating enjoyment, and self-control. Adobe Flash Player is required to view this feature. e1-1242. 28 Several recent trials have also shown that continued contact with participants after weight loss is associated with less regain. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. M. Reported energy intakes and physical activity were similar among the diet groups. CrossRef 136 Vlad Ratziu, Zachary Goodman, Arun Sanyal. Dietary fat is not a major determinant of body fat. Adobe Flash Player is required to view this feature. CrossRef 152 Catherine J Metzgar, Sharon M Nickols-Richardson. CrossRef 161 E E J G Aller, T M Larsen, H Claus, A K Lindroos, A Kafatos, A Pfeiffer, J A Martinez, T Handjieva-Darlenska, M Kunesova, S Stender, W H M Saris, A Astrup, M A van Baak. T. Nutraceuticals and Functional Foods in Human Health and Disease Prevention, 327-340. CrossRef 125 William H Dietz, Louise A Baur, Kevin Hall, Rebecca M Puhl, Elsie M Taveras, Ricardo Uauy, Peter Kopelman. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Figueredo, Etienne J. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Adobe Flash Player is required to view this feature. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Wood, R. Byrne. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Brown. CrossRef 63 Lorayne Robertson, Joli Scheidler-Benns. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. (2015) Predictors of a successful medical weight loss program. CrossRef 119 Sigal Sofer, Abraham Eliraz, Zecharia Madar, Oren Froy. Foreyt. Sister Alice Potts Endowed Lecture Series for Pastoral Education. Phipps. Calvar, F. CrossRef 14 Hans Hauner. Appetite. Ibrahim, Peter Zahradka, Carla G. Solid bars represent high-protein, high-fat, or highest-carbohydrate diets. Stanner. Catching and treating a deadly cancer using a blood test. (2014) Independent, additive effects of five dietary variables on. L. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. e1. CrossRef 180 Lu Qi. Wu. KALMAN. Attendance at group sessions was associated with adherence to the fat and protein goals only in the high-protein and low-fat groups ( Figure 4 ). CrossRef 108 Preeshila Behary, Jaimini Cegla, Tricia M. Of these participants, 325 were assigned to a high-protein diet and 320 to an average-protein diet, 319 were assigned to a high-fat diet and 326 to a low-fat diet, and 169 were assigned to the highest-carbohydrate diet and 168 to the lowest-carbohydrate diet. Long-term weight maintenance and cardiovascular risk factors are not different following weight loss on carbohydrate-restricted diets high in either monounsaturated fat or protein in obese hyperinsulinemic men and women. No diet was considered to be a control diet, and the dietary counseling and the attention that we provided were the same for all diet groups throughout the study period. ) in the treatment of overweight and obese patients with type 2 diabetes: A double-blind randomized controlled trial. Laurie McKnight Schlattman and Bonnie McKnight Endowment Fund for. Intensive lifestyle changes for reversal of coronary heart disease. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Bazzano. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Nutritional and Integrative Strategies in Cardiovascular Medicine, 147-178. Pace, Sheila E. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2014) Causes of metabolic syndrome and obesity-related co-morbidities Part 1: A composite unifying theory review of human-specific co-adaptations to brain energy consumption. The population was diverse with respect to age, income, and geography and included a large percentage of men. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. Pryor. Adobe Flash Player is required to view this feature. Discovery could be a game-changer for the staging of an HPV-related cancer. (2015) Determinants of Weight Gain Prevention in Young Adult and Midlife Women: Study Design and Protocol of a Randomized Controlled Trial. (2016) Behavioral Treatment of the Patient with Obesity. (2015) Medications for weight loss. CrossRef 8 Goreti Botelho, Sara Canas, Jorge Lameiras. (2015) Effect of low-fat diet interventions versus other diet interventions on long-term weight change in adults: a systematic review and meta-analysis. (2015) Dietary Intervention for Overweight and Obese Adults: Comparison of Low-Carbohydrate and Low-Fat Diets. Li, P. Niu, S. (2015) Current efforts and trends in the treatment of NASH. Panel D shows the change in waist circumference for participants who provided measurements at various time-points: 176 to 179 at 6 months, 154 to 166 at 12 months, 135 to 148 at 18 months, and 137 to 159 at 2 years. Results Participants Of 1638 participants who were screened, 811 (50%) were randomly assigned to a diet, and 645 (80% of those assigned) completed the study (i. Krauss. Associations between adherence to the fat and protein goals and weight loss were also explored in post hoc analyses (see Methods in the Supplementary Appendix ). CrossRef 42 A. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2016) Impact of intermittent fasting on health and disease processes. Alternatives for macronutrient intake and chronic disease: a comparison of the OmniHeart diets with popular diets and with dietary recommendations. (2016) Adherence to Mediterranean diet and 10-year incidence (2002-2012) of diabetes: correlations with inflammatory and oxidative stress biomarkers in the ATTICA cohort study.
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